Merck KGaA lifts outlook on drugs, screen chemicals
















DARMSTADT, Germany (Reuters) – Merck KGaA lifted its 2012 outlook on Thursday and beat expectations for third-quarter results as it capitalized on its strong position in the market for chemicals for flat screens.


Family-controlled Merck, which traces its roots to a 17th century pharmacy, now expects adjusted earnings before interest, taxes, depreciation and amortization (EBITDA) this year of 2.90-2.95 billion euros ($ 3.7-$ 3.75 billion).













That is the upper half of its previous target range and compares with 2.9 billion euros expected on average by analysts.


Merck also benefited from continue price increases in the U.S. for multiple sclerosis drugs, where the company sells its established Rebif injection, and from an ongoing cost cutting program.


Third-quarter adjusted EBITDA rose 15.6 percent to 754 million euros, above a forecast for 740 million in a Reuters poll. Revenues also exceeded expectations.


Merck’s dominant position in the market for liquid crystals for flat-panel displays allows it to hold its own even as economic uncertainty puts consumers off big-ticket purchases such as pricey flat-screen TVs. Soaring tablet computer sales also help Merck.


The company is slashing costs and jobs after a number of setbacks in drugs development left it without any significant pharmaceuticals in its late-stage development pipeline.


(Reporting by Ludwig Burger)


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Rolling Stones add fifth date to anniversary tour
















LONDON (Reuters) – The Rolling Stones have added a fifth date to their 50th anniversary tour later this year, the band announced on its website.


In between two shows at London‘s O2 Arena starting on November 25 and two more at the Prudential Center in Newark, NJ opening on December 13 the veteran quartet will play the Barclays Center in Brooklyn, NY on December 8.













Tickets for the fifth concert go on sale on Monday, November 19. The first four gigs quickly sold out despite complaints from many fans over high ticket prices ranging between around 95 pounds ($ 150) and 950 pounds for a VIP seat in London.


On auction website eBay, a pair of ticket with a face value of 406 pounds is on offer for as much as 1,500 pounds.


“You might say, ‘The tickets are too expensive’,” singer Mick Jagger told Billboard magazine in a recent interview.


“Well, it’s a very expensive show to put on, just to do four shows, because normally you do a hundred shows and you’d have the same expenses.”


He added that he did not agree with the secondary ticket market and stressed that the Rolling Stones did not profit from tickets changing hands at inflated prices.


The concerts celebrating 50 years of the band behind hits like “(I Can’t Get No) Satisfaction” and “Honky Tonk Women” are part of a series of events marking the milestone including a new documentary, a photograph book and a greatest hits album.


The music press has been rife with speculation that the Stones could launch a full world tour next year including a set at the Glastonbury music festival.


(Reporting by Mike Collett-White, editing by Paul Casciato)


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Who's who in the Petraeus scandal

What started out as a leisurely stroll through the Philadelphia Museum of Art on Nov. 11 with his girlfriend, quickly turned into quite a surreal experience for Max Galuppo, 20, of Bloomsbury, N.J. Galuppo, a Temple University student, found his doppelganger in a 16th century...
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General investigated for emails to Petraeus friend
















PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged “inappropriate communications” with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.


Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.













Panetta said that he ordered a Pentagon investigation of Allen on Monday.


A senior defense official traveling with Panetta said Allen’s communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.


Kelley is said to have received threatening emails from Broadwell, who is Petraeus’ biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.


Petraeus resigned as CIA director on Friday.


Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.


The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen’s problematic communications.


The official said 20,000 to 30,000 pages of emails and other documents from Allen’s communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.


“Gen. Allen disputes that he has engaged in any wrongdoing in this matter,” the official said. He said Allen currently is in Washington.


Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.


The FBI’s decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta’s decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.


Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.


In the meantime, Panetta said, Allen’s nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold “until the relevant facts are determined.” He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.


Panetta said President Barack Obama was consulted and agreed that Allen’s nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.


NATO officials had no comment about the delay in Allen’s appointment.


“We have seen Secretary Panetta‘s statement,” NATO spokeswoman Carmen Romero said in Brussels. “It is a U.S. investigation.”


Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama’s nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford’s hearing is also scheduled for Thursday.


___


Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.


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Papa John’s falls on news of class-action suit
















NEW YORK (AP) — Shares of Papa John‘s declined on Tuesday following news of class-action certification for a lawsuit that claims the pizza chain had unsolicited text messages sent to cell phones.


THE SPARK: The lawsuit filed with the U.S. District Court for the Western District of Washington in Seattle claims Papa John‘s violated state and federal law when they had the marketing company OnTime4U send unsolicited text messages on its behalf to cell phones advertising their pizza products. The lawsuit says that 500,000 illegal text messages were sent to Papa John’s customers across the U.S.













Papa John’s faces potential damages of more than $ 250 million. The plaintiffs may each potentially receive $ 500 or more in damages for each text message.


Messages left with Papa John’s seeking comment were not immediately returned.


SHARE ACTION: Papa John’s International Inc.’s stock fell 34 cents to $ 49.10 in afternoon trading after dropping as low as $ 46.72 earlier in the session. Over the past year, the shares have traded in a range of $ 35.21 to $ 56.41.


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Merck scraps combination diabetes drug
















(Reuters) – Merck & Co no longer plans to develop a drug to treat type 2 diabetes that would have combined its largest selling diabetes drug, Januvia, with a generic version of Pfizer Inc‘s cholesterol drug Lipitor.


Merck, one of the country’s largest drugmakers, said in a regulatory filing on Friday that it decided to stop clinical development of the program for business reasons.













The decision is not related to any concerns about the safety of the two drugs, according to Merck spokeswoman Pam Eisele.


According to the company’s website, the drug, which was called MK-0431E, was in late-stage development.


Merck already sells Juvisync, a combination of Januvia with simvastatin, a member of the statin class of cholesterol fighters that include Lipitor. Merck sells simvastatin, which is almost as potent in cutting “bad” LDL cholesterol as Lipitor, under the brand name Zocor. Many other drugmakers sell generic forms of simvastatin.


Companies have been testing combination drugs as they look for ways to cut down on the number of medications that individuals use.


Merck shares were up 0.4 percent at $ 44.18 in early afternoon trading.


The company has estimated that 20 million people in the United States have type 2 diabetes, an illness closely linked to obesity and the most common form of diabetes.


Sufferers of the disease often also have high cholesterol levels, which raise the risk of heart attack, stroke and other cardiovascular problems.


(Reporting By Caroline Humer; Editing by Steve Orlofsky)


Medications/Drugs News Headlines – Yahoo! News



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‘Sesame Street’ Elmo puppeteer takes leave amid sex scandal
















LOS ANGELES (Reuters) – The puppeteer and voice behind the character Elmo on “Sesame Street” has taken a leave of absence from the children’s television show following allegations that he had a sexual relationship with a 16-year-old boy, producers said on Monday.


New York-based Sesame Workshop said in a statement that its own inquiry concluded that the claim of underage sexual conduct was unsubstantiated, and that puppeteer Kevin Clash has denied any wrongdoing and called the allegation “false and defamatory.”













But the company said Clash, 52, was disciplined after an internal investigation showed he “exercised poor judgment and violated company policy regarding Internet usage.”


The Sesame Workshop statement said the puppeteer was “taking actions to protect his reputation” and that Sesame Workshop has “granted him a leave of absence to do so.”


Neither Clash nor his personal publicist was immediately available for comment.


CNN quoted a statement from Clash acknowledging a relationship with his accuser but denying he had sexual contact with a minor.


“I am a gay man. I have never been ashamed of this or tried to hide it,” it quoted him as saying. “I had a relationship with the accuser, it was between two consenting adults, and I am deeply saddened that he is characterizing it as something other than what it was.”


The statement went on to say, “I’m taking a break from Sesame Workshop to deal with this false and defamatory allegation.”


Sesame Workshop said the matter came to its attention when it received a communication in June from accuser, now aged 23, alleging that he had a relationship with Clash beginning when he was 16 years old.


“We took the allegation very seriously and took immediate action,” the company said, adding that it met with the accuser twice and had “repeated communications with him.” The company said it also discussed the matter with Clash, who denied the allegations.


A spokeswoman for the show said she did not know whether law enforcement authorities were looking into the allegations.


Clash officially joined the “Sesame Street” cast in 1984, assuming the Elmo role that year.


Elmo’s character had debuted on the show in 1979, and though Clash was the third performer to animate the child-like shaggy red monster, Sesame Workshop credits him with turning Elmo into the international sensation he became.


For now, producers promised that Elmo would remain on the show despite the absence of Clash, saying “Elmo is bigger than any one person and will continue to be an integral part of ‘Sesame Street.’”


(Reporting and writing by Steve Gorman; Editing by Cynthia Johnston and Cynthia Osterman)


TV News Headlines – Yahoo! News



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Petraeus probe ensnares top U.S. commander in Afghanistan

PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged "inappropriate communications" with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.

Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.

Panetta said that he ordered a Pentagon investigation of Allen on Monday.

A senior defense official traveling with Panetta said Allen's communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.

Kelley is said to have received threatening emails from Broadwell, who is Petraeus' biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.

Petraeus resigned as CIA director on Friday.

Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.

The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen's problematic communications.

The official said 20,000 to 30,000 pages of emails and other documents from Allen's communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.

"Gen. Allen disputes that he has engaged in any wrongdoing in this matter," the official said. He said Allen currently is in Washington.

Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.

The FBI's decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta's decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.

Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.

In the meantime, Panetta said, Allen's nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold "until the relevant facts are determined." He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.

Panetta said President Barack Obama was consulted and agreed that Allen's nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.

NATO officials had no comment about the delay in Allen's appointment.

"We have seen Secretary Panetta's statement," NATO spokeswoman Carmen Romero said in Brussels. "It is a U.S. investigation."

Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama's nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford's hearing is also scheduled for Thursday.

___

Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.

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Canada seen needing to spell out rules for natural gas projects
















CALGARY, Alberta (Reuters) – The fate of a handful of liquefied natural gas projects planned for Canada’s Pacific coast may depend on the Canadian government‘s willingness to spell out rules for foreign investment in the country’s energy sector, according to a study released on Thursday.


Apache Corp, Royal Dutch Shell Plc, Petronas, BG Group Plc and others are in the planning stages for LNG projects that would take gas from the rich shale fields of northeastern British Columbia and ship it to Asian buyers.













But the federal government’s decision last month to stall the C$ 5.2 billion ($ 5.2 billion) bid by Malaysia’s state-owned Petronas C$ 5.2 billion for Canada‘s Progress Energy Resources Corp could lessen the appetite of Asian buyers for Canadian LNG, energy consultants Wood Mackenzie said.


“Some potential off-takers of Canadian LNG like the idea … because it’s perceived as having low political risk, and another reason is because they see the potential for investment opportunities,” said Noel Tomnay, head of global gas at the consultancy.


“If there are going to be restrictions on how they access those opportunities, if acquisitions are closed to them, then clearly that would restrict the attractiveness of those opportunities. If would-be Asian investors thought that corporate acquisitions were an avenue that was not open to them then Canadian LNG would become less attractive.”


The Canadian government is looking to come up with rules governing corporate acquisitions by state-owned companies and has pushed off a decision on the Petronas bid as it considers whether to approve the $ 15.1 billion offer for Nexen Inc from China’s CNOOC Ltd.


Exporting LNG to Asia is seen as a way to boost returns for natural-gas producers tapping the Montney, Horn River and Liard Basin shale regions of northeastern British Columbia.


Though Wood Mackenzie estimates the fields contain as much as 280 trillion cubic feet of gas, they are far from Canada’s traditional U.S. export market, while growing supplies from American shale regions have cut into Canadian shipments.


Because the region lacks infrastructure, developing the resource will be expensive, requiring new pipelines and multibillion-dollar liquefaction.


Still Wood Mackenzie estimates that the cost of delivery into Asian markets for Canadian LNG would be in the range of $ 10 million to $ 12 per million British thermal units, similar to competing projects in the United States and East Africa.


($ 1 = $ 1.00 Canadian)


(Reporting by Scott Haggett; Editing by Leslie Adler)


Canada News Headlines – Yahoo! News



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Mushroom Poisonings Spike as 2 Die
















The accidental deaths of two California women from mushroom poisoning comes at a time of mounting reports of poisoning from wild toadstools across the county, according to a prominent liver specialist.


The two elderly women died after a caregiver at their senior care facility inadvertently served them a meal with poison mushrooms picked on the Loomis, Calif., property.













The caregiver and three other residents of Gold Age Villa remain hospitalized, according to WTEN-TV, the ABC News affiliate in Sacramento.


Teresa Olesniewicz, 73, died Friday morning, and Barbara Lopes, 86 died Friday night, according to the county coroner.


“It looks like a tragic accident,” Lt. Mark Reed of the Placer County Sheriff’s Department said.


Reed told the Sacramento Bee that the caregiver “just didn’t know” the mushrooms were poisonous. It is not clear what kind of mushroom the victims ate, however.


Dr. Pierre Gholam, a liver specialist at University Hospitals in Cleveland, said he has seen an uptick in wild mushroom poisonings in his area, too. More than two dozen patients have arrived in the past three years with telltale mushroom poisoning symptoms, he said, including diarrhea followed by kidney and liver failure.


Gholam, who spoke to ABC News by phone from the 63rd annual meeting of the American Association for the Study of Liver Diseases in Boston, said doctors there from across the country report similar increases in mushroom poisoning patients, even in areas not typically known for mushroom poisonings, such as the Midwest.


Specialists historically see case clusters in Northern California and in the Northeast.


“Clearly, there is something that has changed in my mind that has led to more mushroom poisoning cases,” he said. “It looks like a nationwide phenomenon.”


The reasons are unclear but Gholam suggested that more people could be picking their own mushrooms in the bad economy to save money.


Gholam’s hospital is one of only a few that are authorized by the federal government to give patients an antidote called silibinin, which blocks the poison from attacking the liver. As such, 14 patients have come from up to 150 miles away for the life-saving drug.


The poison in these mushrooms is called amatoxin, and it’s colorless and odorless, so people who pick or eat them won’t know until it’s too late, Gholam said. The poison fungi can also come in different sizes and shapes. Cooking or freezing the mushrooms does not deactivate the toxin.


Typically, people begin to feel sick within six hours of eating the mushrooms, and come down with severe diarrhea, which causes dehydration and kidney failure, he said. Without the antidote, liver failure sets in after 72 hours, and the patient has either died or needs a liver transplant after 96 hours.


“I think at this point, it is absolutely critical to spread the word — especially to folks that picked mushrooms — that the landscape has changed,” Gholam said.


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