Apple rolls out iPad mini in Asia to shorter lines

SYDNEY (Reuters) - Apple fans lined up in several Asian cities to get their hands on the iPad mini on Friday, but the device, priced above rival gadgets from Google and Amazon.com, attracted smaller crowds than at the company's previous global rollouts.

Apple Inc's global gadget rollouts are typically high-energy affairs drawing droves of buyers who stand in line for hours. But a proliferation of comparable rival devices may have sapped some interest.

About 50 people waited for the Apple store in Sydney, Australia, to open, where in the past the line had stretched for several blocks when the company debuted new iPhones.

At the head of Friday's line was Patrick Li, who had been waiting since 4:30 am and was keen to get his hands on the 7.9-inch slate.

"It's light, easy to handle, and I'll use it to read books. It's better than the original iPad," Li said.

There were queues of 100 or more outside Apple stores in Tokyo and Seoul when the device went on sale, but when the company's flagship Hong Kong store opened staff appeared to outnumber those waiting in line.

The iPad mini marks Apple's first foray into the smaller-tablet segment, and the latest salvo in a global mobile-device war that has engulfed combatants from Internet search leader Google Inc to Web retailer Amazon.com Inc and software giant Microsoft Corp.

Microsoft's 10-inch Surface tablet, powered by the just-launched Windows 8 software, went on sale in October, while Google and Amazon now dominate sales of smaller, 7-inch multimedia tablets.

POSITIVE REVIEWS

Unveiled last week, the iPad mini has won mostly positive reviews, with criticism centering on a screen considered inferior to rivals' and a lofty price tag. The new tablet essentially replicates most of the features of its full-sized sibling, but in a smaller package.

"Well, first of all it's so thin and light and very cute - so cute!" said iPad mini customer Ten Ebihara at the Apple store in Tokyo's upscale Ginza district.

At $329 for a Wi-Fi only model, the iPad mini is a little costlier than predicted but some analysts see that as Apple's attempt to retain premium positioning.

Some investors fear the gadget will lure buyers away from Apple's $499 flagship 9.7-inch iPad, while proving ineffective in combating the threat of Amazon's $199 Kindle Fire and Google's Nexus 7, both of which are sold at or near cost.

Also on Friday, Apple rolled out its fourth-generation iPad, with the same 9.7-inch display as the previous version but with a faster A6X processor and better Wi-Fi. Both devices were going on sale in more than 30 countries.

Apple will likely sell between 1 million and 1.5 million iPad minis in the first weekend, far short of the 3 million third-generation iPads sold last March in their first weekend, according to Piper Jaffray analyst Gene Munster.

"The reason we expect fewer iPad minis compared to the 3rd Gen is because of the lack of the wireless option and newness of the smaller form factor for consumers," Munster said in a note to clients. "We believe that over time that will change."

Reviewers have applauded Apple for squeezing most of the iPad's features into a smaller package that can be comfortably manipulated with one hand.

James Vohradsky, a 20 year-old student who previously queued for 17 hours at the Sydney store to buy the iPhone 5, only stood in line for an hour and a half this time.

"I had an iPad 1 before, I kind of miss it because I sold it about a year ago. It's just more practical to have the mini because I found it a bit too big. The image is really good and it's got the fast A5 chip too," Vohradsky said.

The iPad was launched in 2010 by late Apple boss Steve Jobs and since then it has taken a big chunk out of PC sales, upending the industry and reinventing mobile computing with its apps-based ecosystem.

A smaller tablet is the first device to be added to Apple's compact portfolio under Cook, who took over from Jobs just before his death a year ago. Analysts credit Google and Amazon for influencing the decision.

Some investors worry that Apple might have lost its chief visionary with Jobs, and that new management might not be able to stay ahead of the pack as rivals innovate and encroach on its market share.

(Additional reporting by Mariko Lochridge in Tokyo, Stefanie McIntyre in Hong Kong and Miyoung Kim in Seoul; Writing by Noel Randewich and Edwin Chan in San Francisco; Editing by Phil Berlowitz and Alex Richardson)

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Floods render NYC hospitals powerless

NEW YORK (AP) — There are few places in the U.S. where hospitals have put as much thought and money into disaster planning as New York. And yet two of the city’s busiest, most important medical centers failed a fundamental test of readiness during Superstorm Sandy this week: They lost power.

Their backup generators failed, or proved inadequate. Nearly 1,000 patients had to be evacuated.

The closures led to dramatic scenes of doctors carrying patients down dark stairwells, nurses operating respirators by hand, and a bucket brigade of National Guard troops hauling fuel to rooftop generators in a vain attempt to keep the electricity on.

Both hospitals, NYU Langone Medical Center and Bellevue Hospital Center, were still trying to figure out exactly what led to the power failures Thursday, but the culprit appeared to be the most common type of flood damage there is: water in the basement.

While both hospitals put their generators on high floors where they could be protected in a flood, other critical components of the backup power system, such as fuel pumps and tanks, remained in basements just a block from the East River.

Both hospitals had fortified that equipment against floods within the past few years, but the water — which rushed with tremendous force — found a way in.

“This reveals to me that we have to be much more imaginative and detail-oriented in our planning to make sure hospitals are as resilient as they need to be,” said Irwin Redlener, director of the National Center for Disaster Preparedness at Columbia University’s Mailman School of Public Health.

The problem of unreliable backup electricity at hospitals is nothing new.

Over the first six months of the year, 23 percent of the hospitals inspected by the Joint Commission, a health care facility accreditation group, were found to be out of compliance with standards for backup power and lighting, according to a spokesman.

Power failures crippled New Orleans hospitals after Hurricane Katrina. The backup generator failed at a hospital in Stafford Springs, Conn., after the remnants of Hurricane Irene blew through the state in 2011. Hospitals in Houston were crippled when Tropical Storm Allison flooded their basements and knocked out electrical equipment in 2001.

When the Northeast was hit with a crippling blackout in 2003, the backup power at several of New York City’s hospitals failed or performed poorly. Generators malfunctioned or overheated. Fuel ran out too quickly. Even where the backup systems worked, they provided electricity to only some parts of the hospital and left others in the dark.

Afterward, a mayoral task force recommended upgrading testing standards for generators and requiring backup plans for blood banks and health care facilities that provide dialysis treatment.

Alan Aviles, president of New York City’s Health and Hospitals Corp., which operates Bellevue, said that after a scare last summer when Hurricane Irene threatened to cause flooding, Bellevue put its basement-level fuel pumps in flood-resistant chambers.

It still isn’t clear whether water breached those defenses, but when an estimated 17 million gallons of water rushed through loading docks and into the hospital’s 1-million-square-foot basement, the fuel feed to the generators stopped working. The floodwaters also knocked out the hospital’s elevators.

For two days, National Guardsmen carried fuel to the generators, but conditions inside the hospital for patients and staff deteriorated anyway. The generators were designed to supply only 30 percent of the usual electrical load at the hospital, leaving a lot of equipment and labs hobbled. The hospital also lost all water pressure on Tuesday. Nearly 700 patients had been evacuated by Thursday afternoon.

“The precautions we had taken to date had served us well,” Aviles said. “But Mother Nature can always up the stakes.”

NYU Langone Medical Center had also tried to armor itself against floods.

All seven of the generators providing backup power to the parts of the hospital involved in patient care are only a few years old and are on higher floors. The fuel tank is in a watertight vault. New fuel pumps were installed just this year in a pump house upgraded to withstand a high flood, said the hospital’s vice president of facilities operation, Richard Cohen.

“The medical center invested quite a bit of money to upgrade the facility,” he said.

The pump house remained “bone dry,” Cohen said. But water shoved aside plastic and plywood defenses and infiltrated the fuel vault, where sensors detected the potentially damaging liquid and shut the generators down. “The force of the surge that came in was unbelievable. It dislodged our additional protection and caused a breach of the vault as well,” Cohen said.

The power at NYU went out in a flash, leaving the staff scrambling to evacuate 300 patients with no notice.

Dr. Robert Berg, an obstetrician, said that when he lost power in his apartment, he went to the hospital to charge his cellphone and was stunned to find it in chaos.

“It didn’t really occur to me that the hospital was going to be in trouble,” he said. Even after finding the lobby dark, “I thought, ‘We’ll have power upstairs. We’re an operating room.’”

He wound up carrying two patients down flights of stairs on a “med sled.”

“There was a Category 1 outside and a Category 4 inside,” he said. “I can’t say that they were very well prepared for it.”

That has left only one hospital, Beth Israel Medical Center, functioning in the southern third of Manhattan. It is also on backup power, but brought in two huge new generators Thursday, just in case.

Aviles said Bellevue might be out of commission for at least two more weeks. NYU Langone’s generators are operating again, but the hospital is waiting for Consolidated Edison to restore its power before it starts taking patients again. That could happen in a matter of days.

Flooding may pose less of a danger to the hospital’s power supply in the future. Construction is under way on a new power plant, at a cost of more than $ 200 million, that will run on natural gas and supply all the hospital’s power needs.

“It’s a tremendous facility, with a lot of hardening built into it,” Cohen said.

___

AP Medical Writer Mike Stobbe contributed to this report.

Health News Headlines – Yahoo! News

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George Clooney is distant cousin of Abraham Lincoln

LOS ANGELES (Reuters) – Aunt Rosemary was not George Clooney‘s only famous relative. You can add a certain Civil War American president to the Oscar-winning actor’s family tree.

Politics has apparently run in the activist actor’s blood for centuries, as website Ancestry.com on Thursday revealed that the “Ocean’s 11″ star is distantly related to President Abraham Lincoln.

According to Ancestry.com, Clooney is the half-first cousin five times removed from Lincoln, the 16th president. The genealogy website breaks down the connection, explaining the “half” means that two of their ancestors were half-siblings – Lincoln’s mother Nancy Hanks was the half-sister of Clooney’s 4th great-grandmother Mary Ann Sparrow.

Hanks and Sparrow shared the same mother, Lucy Hanks, but had different fathers. Lucy Hanks was Lincoln’s maternal grandmother as well as the 5th great-grandmother of Clooney.

Clooney’s aunt was singer and actress Rosemary Clooney, who died in 2002.

Clooney, long noted for his political activism, is a major Hollywood backer of President Barack Obama. He hosted a Democratic Party fundraiser at his Los Angeles home in March that raised $ 15 million.

Lincoln, a Republican, is considered one of the greatest presidents in the history of the United States. He led the country through the Civil War and is credited with the abolition of slavery, which officially became law in 1865 after his assassination.

He is the subject of an upcoming Steven Spielberg film “Lincoln,” starring Daniel Day-Lewis in the title role, which is to open in the United States next week.

Ancestry.com is offering free access to more than 20,000 documents showcasing Lincoln’s life, his family tree and the most pivotal moments of his presidential career. The details can be found at www.ancestry.com/lincoln.

(Reporting by Zorianna Kit; Editing by Chris Michaud and Jackie Frank)

Celebrity News Headlines – Yahoo! News

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Thousands still trapped in homes after Sandy

NEW YORK, N.Y. - People along the battered U.S. East Coast slowly began reclaiming their daily routines Thursday, even as crews searched for victims and tens of thousands remained without power after superstorm Sandy claimed more than 70 lives.

The New York Stock Exchange came back to life, and two major New York airports reopened to begin the long process of moving stranded travellers around the world.

New York's three major airports were expected to be open Thursday morning with limited flights. Limited service on the subway, which suffered the worst damage in its 108-year history, would resume Thursday.

President Barack Obama landed in New Jersey on Wednesday, which was hardest hit by Monday's hurricane-driven storm, and he took a helicopter tour of the devastation with Gov. Chris Christie. "We're going to be here for the long haul," Obama told people at one emergency shelter.

For the first time since the storm pummeled the heavily populated Northeast, doing billions of dollars in damage, brilliant sunshine washed over New York City, for a while.

At the stock exchange, running on generator power, Mayor Michael Bloomberg gave a thumbs-up and rang the opening bell to whoops from traders. Trading resumed after the first two-day weather shutdown since a blizzard in 1888.

It was clear that restoring the region to its ordinarily frenetic pace could take days — and that rebuilding the hardest-hit communities and the transportation networks could take considerably longer.

There were still only hints of the economic impact of the storm.

Forecasting firm IHS Global Insight predicted it would cause $20 billion in damage and $10 billion to $30 billion in lost business. Another firm, AIR Worldwide, estimated losses up to $15 billion.

About 6 million homes and businesses were still without power, mostly in New York and New Jersey. Electricity was out as far west as Wisconsin in the Midwest and as far south as the Carolinas.

In New Jersey, National Guard troops arrived in the heavily flooded city of Hoboken, just across the river from New York City, to help evacuate about 20,000 people still stuck in their homes and deliver ready-to-eat meals. Live wires dangled in floodwaters that Mayor Dawn Zimmer said were rapidly mixing with sewage.

Tempers flared. A man screamed at emergency officials in Hoboken about why food and water had not been delivered to residents just a few blocks away. The man, who would not give his name, said he blew up an air mattress to float over to a staging area.

As New York crept toward a semi-normal business day, morning rush-hour traffic was heavy as buses returned to the streets and bridges linking Manhattan to the rest of the world were open.

A huge line formed at the Empire State Building as the observation deck reopened.

Tourism returned, but the city's vast and aging infrastructure remained a huge challenge.

Power company Consolidated Edison said it could be the weekend before power is restored to Manhattan and Brooklyn, perhaps longer for other New York boroughs and the New York suburbs.

Amtrak said the amount of water in train tunnels under the Hudson and East rivers was unprecedented, but it said it planned to restore some service on Friday to and from New York City — its busiest corridor — and would give details Thursday.

In Connecticut, some residents of Fairfield returned home in kayaks and canoes to inspect widespread damage left by retreating floodwaters that kept other homeowners at bay.

"The uncertainty is the worst," said Jessica Levitt, who was told it could be a week before she can enter her house. "Even if we had damage, you just want to be able to do something. We can't even get started."

In New York, residents of the flooded beachfront neighbourhood of Breezy Point returned home to find fire had taken everything the water had not. A huge blaze destroyed perhaps 100 homes in the close-knit community where many had stayed behind despite being told to evacuate.

John Frawley, who lived about five houses from the fire's edge, said he spent the night terrified "not knowing if the fire was going to jump the boulevard and come up to my house."

"I stayed up all night," he said. "The screams. The fire. It was horrifying."

___

Contributors to this report included Associated Press writers Angela Delli Santi in Belmar, New Jersey; Geoff Mulvihill and Larry Rosenthal in Trenton, New Jersey; Katie Zezima in Atlantic City, New Jersey; Samantha Henry in Jersey City, New Jersey; Pat Eaton-Robb and Michael Melia in Hartford, Connecticut; Susan Haigh in New London, Connecticut; John Christoffersen in Bridgeport, Connecticut; Alicia Caldwell and Martin Crutsinger in Washington; David Klepper in South Kingstown, Rhode Island; David B. Caruso, Colleen Long, Jennifer Peltz, Tom Hays, Larry Neumeister, Ralph Russo and Scott Mayerowitz in New York.

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Clinton calls for overhaul of Syrian opposition

ZAGREB (Reuters) – The United States called on Wednesday for an overhaul of Syria‘s opposition leadership, saying it was time to move beyond the Syrian National Council and bring in those “in the front lines fighting and dying”.

Secretary of State Hillary Clinton, signaling a more active stance by Washington in attempts to form a credible political opposition to Syrian President Bashar al-Assad, said a meeting next week in Qatar would be an opportunity to broaden the coalition against him.

“This cannot be an opposition represented by people who have many good attributes but who, in many instances, have not been inside Syria for 20, 30, 40 years,” she said during a visit to Croatia.

“There has to be a representation of those who are in the front lines fighting and dying today to obtain their freedom.”

Clinton’s comments represented a clear break with the Syrian National Council (SNC), a largely foreign-based group which has been among the most vocal proponents of international intervention in the Syrian conflict.

U.S. officials have privately expressed frustration with the SNC’s inability to come together with a coherent plan and with its lack of traction with the disparate internal groups which have waged the 19-month uprising against Assad’s government.

Senior members of the SNC, Free Syrian Army (FSA) and other rebel groups ended a meeting in Turkey on Wednesday and pledged to unite behind a transitional government in coming months.

“It’s been our divisions that have allowed the Assad forces to reach this point,” Ammar al-Wawi, a rebel commander, told Reuters after the talks outside Istanbul.

“We are united on toppling Assad. Everyone, including all the rebels, will gather under the transitional government.”

Mohammad Al-Haj Ali, a senior Syrian military defector, told a news conference after the meeting: “We are still facing some difficulties between the politicians and different opposition groups and the leaders of the Free Syrian Army on the ground.”

Clinton said it was important that the next rulers of Syria were both inclusive and committed to rejecting extremism.

“There needs to be an opposition that can speak to every segment and every geographic part of Syria. And we also need an opposition that will be on record strongly resisting the efforts by extremists to hijack the Syrian revolution,” she said.

Syria’s revolt has killed an estimated 32,000. A bomb near a Shi’ite shrine in a suburb of Damascus killed at least six more people on Wednesday, state media and opposition activists said.

NEW LEADERSHIP

The meeting next week in Qatar’s capital Doha represents a chance to forge a new leadership, Clinton said, adding the United States had helped to “smuggle out” representatives of internal Syrian opposition groups to a meeting in New York last month to argue their case for inclusion.

“We have recommended names and organizations that we believe should be included in any leadership structure,” she told a news conference.

“We’ve made it clear that the SNC can no longer be viewed as the visible leader of the opposition. They can be part of a larger opposition, but that opposition must include people from inside Syria and others who have a legitimate voice which must be heard.”

The United States and its allies have struggled for months to craft a credible opposition coalition.

U.S. President Barack Obama’s administration has said it is not providing arms to internal opponents of Assad and is limiting its aid to non-lethal humanitarian assistance.

It concedes, however, that some of its allies are providing lethal assistance – a fact that Assad’s chief backer Russia says shows western powers are intent on determining Syria’s future.

Russia and China have blocked three U.N. Security Council resolutions aimed at increasing pressure on the Assad government, leading the United States and its allies to say they could move beyond U.N. structures for their next steps.

Clinton said she regretted but was not surprised by the failure of the latest attempted ceasefire, called by international mediator Lakhdar Brahimi last Friday. Each side blamed the other for breaking the truce.

“The Assad regime did not suspend its use of advanced weaponry against the Syrian people for even one day,” she said.

“While we urge Special Envoy Brahimi to do whatever he can in Moscow and Beijing to convince them to change course and support a stronger U.N. action we cannot and will not wait for that.”

Clinton said the United States would continue to work with partners to increase sanctions on the Assad government and provide humanitarian assistance to those hit by the conflict.

(Additional reporting by Ayla Jean Yackley; editing by Andrew Roche)

World News Headlines – Yahoo! News

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Apple's Cook fields his A-team before a wary Wall Street

SAN FRANCISCO (Reuters) - Apple Inc Chief Executive Tim Cook's new go-to management team of mostly familiar faces failed to drum up much excitement on Wall Street, driving its shares to a three-month low on Wednesday.

The world's most valuable technology company, which had faced questions about a visionary-leadership vacuum following the death of Steve Jobs, on Monday stunned investors by announcing the ouster of chief mobile software architect Scott Forstall and retail chief John Browett -- the latter after six months on the job.

Cook gave most of Forstall's responsibilities to Macintosh software chief Craig Federighi, while some parts of the job went to Internet chief Eddy Cue and celebrated designer Jony Ive.

But the loss of the 15-year veteran and Jobs's confidant Forstall, and resurgent talk about internal conflicts, exacerbated uncertainty over whether Cook and his lieutenants have what it takes to devise and market the next ground-breaking, industry-disrupting product.

Apple shares ended the day down 1.4 percent at 595.32. They have shed a tenth of their value this month -- the biggest monthly loss since late 2008, and have headed south since touching an all-time high of $705 in September.

For investors, the management upheaval from a company that usually excels at delivering positive surprises represents the latest reason for unease about the future of a company now more valuable than almost any other company in the world.

Apple undershot analysts targets in its fiscal third quarter, the second straight disappointment. Its latest Maps software was met with widespread frustration and ridicule over glaring mistakes. Sources told Reuters that Forstall and Cook disagreed over the need to publicly apologize for its maps service embarrassment.

And this month, Apple entered the small-tablet market with its iPad mini, lagging Amazon.com Inc and Google Inc despite pioneering the tablet market in 2010.

Investor concerns now center around the demand, availability and profitability of new products, including the iPad mini set to hit stores on Friday.

"The sudden departure of Scott Forstall doesn't help," said Shaw Wu, an analyst with Sterne Agee. "Now there's some uncertainty in the management."

"There appears to be some infighting, post-Steve Jobs, and looks like Cook is putting his foot down and unifying the troops."

Apple declined to comment beyond Monday's announcement.

Against that backdrop, Cook's inner circle has some convincing to do. In the wake of Forstall's exit, iTunes maestro Eddy Cue -- dubbed "Mr Fixit", the sources say -- gets his second promotion in a year, taking on an expanded portfolio of all online services, including Siri and Maps.

The affable executive with a tough negotiating streak who, according to documents revealed in court, lobbied Jobs aggressively and finally convinced the late visionary about the need for a smaller-sized tablet, has become a central figure: a versatile problem-solver for the company.

Ive, the British-born award-winning designer credited with pushing the boundaries of engineering with the iPod and iPhone, now extends his skills into the software realm with the lead on user interface.

Marketing guru Schiller continues in his role, while career engineer Mansfield canceled his retirement to stay on and lead wireless and semiconductor teams. Then there's Federighi, the self-effacing software engineer who a source told Reuters joined Apple over Forstall's initial objections, and has the nickname "Hair Force One" on Game Center.

"With a large base of approximately 60,400 full-time employees, it would be easy to conclude that the departures are not important," said Keith Bachman, analyst with BMO Capital Markets. "However, we do believe the departures are a negative, since we think Mr. Forstall in particular added value to Apple."

TEAM COOK

Few would argue with Forstall's success in leading mobile software iOS and that he deserves a lot of credit for the sale of millions of iPhones and iPads.

But despite the success, his style and direction on the software were not without critics, inside and outside.

Forstall often clashed with other executives, said a person familiar with him, adding he sometimes tended to over-promise and under-deliver on features. Now, Federighi, Ive and Cue have the opportunity to develop the look, feel and engineering of the all-important software that runs iPhones and iPads.

Cue, who rose to prominence by building and fostering iTunes and the app store, has the tough job of fixing and improving Maps, unveiled with much fanfare by Forstall in June, but it was found full of missing information and wrongly marked sites.

The Duke University alum and Blue Devils basketball fan -- he has been seen courtside with players -- is deemed the right person to accomplish this, given his track record on fixing services and products that initially don't do well.

The 23-year veteran turned around the short-lived MobileMe storage service after revamping and wrapping it into the reasonably well-received iCloud offering.

"Eddy is certainly a person who gets thrown a lot of stuff to ‘go make it work' as he's very used to dealing with partners," said a person familiar with Cue. The person said Cue was suited to fixing Maps given the need to work with partners such as TomTom and business listings provider Yelp.

Cue's affable charm and years of dealing with entertainment companies may come in handy as he also tries to improve voice-enabled digital assistant Siri. He has climbed the ladder rapidly in the past five years and was promoted to senior vice president last September, shortly after Cook took over as CEO.

Both Cue and Cook will work more closely with Federighi, who spent a decade in enterprise software before rejoining Apple in 2009, taking over Mac software after the legendary Bertrand Serlet left the company in March last year

Federighi was instrumental in bringing popular mobile features such as notifications and Facebook integration onto the latest Mac operating system Mountain Lion, which was downloaded on 3 million machines in four days.

The former CTO of business software company Ariba, now part of SAP, worked with Jobs at NeXT Computer. Federighi is a visionary in software engineering and can be as good as Jobs in strategic decisions for the product he oversees, a person who has worked with him said.

His presentation skills have been called on of late, most recently at Apple annual developers' gathering in the summer.

Then there's Ive, deemed Apple's inspirational force. Among the iconic products he has worked on are multi-hued iMac computers, the iPod music player, the iPhone and the iPad.

Forstall's departure may free Ive of certain constraints, the sources said. His exit brought to the fore a fundamental design issue -- to do or not to do digital skeuomorphic designs. Skeuomorphic designs stay true to and mimic real-life objects, such as the bookshelf in the iBooks icon, green felt in its Game Center app icon, and an analog clock depicting the time.

Forstall, who will stay on as adviser to Cook for another year, strongly believed in these designs, but his philosophy was not shared by all. His chief dissenter was Ive, who is said to prefer a more open approach, which could mean a slightly different design direction on the icons.

"There is no one else who has that kind of (design) focus on the team," the person said of Ive. "He is critical for them."

(Additional reporting by Alistair Barr; Editing by Edwin Chan and Ken Wills)

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Ivermectin hair lotion found effective against lice

NEW YORK (Reuters Health) – A single 10-minute hair application of a drug used in oral form since the 1980s to control river blindness and other parasitic diseases eliminated head lice in nearly three of four children in a new study.

The lotion contains ivermectin and is sold under the brand name Sklice by Sanofi Pasteur, which paid for the study. The U.S. Food and Drug Administration used the results to approve topical ivermectin lotion in February.

“The advantage of it is, it’s a one-application, one-shot treatment,” lead author Dr. David Pariser of Eastern Virginia Medical School, in Norfolk, told Reuters Health.

The treatment “sounds like it has promise in a population itching to get rid of lice,” said Dr. Hannah Chow of Loyola University Health System in Illinois, who was not connected with the study.

“Knowing how difficult it is to completely remove all lice despite due diligence with treatment and nit picking, ivermectin has potential to reduce the spread of lice, thus reducing parental anxiety, missed school and work, and social embarrassment,” she said.

Hundreds of people worldwide suffer from head lice, which feed off blood and lay up to 300 eggs, which are the nits, during a month-long lifespan.

The cost of treating infestations – including the value of lost school days and parents forced to be out of work – is estimated at $ 1 billion a year in the United States. There’s also been concern about resistance to other insecticide treatments.

Using a lotion with 0.5 percent ivermectin, the researchers found that after 14 days it had worked in 73.8 percent of 141 volunteers – most of whom were children younger than 12. In comparison, 17.6 percent of the 148 kids (and a handful of adults) whose hair was treated with a drug-free form of the lotion were louse-free after two weeks.

Lotions were applied to dry hair and then rinsed out after 10 minutes. The immediate success rate, judged the day after the lotion application, was 94.9 percent in the test group and 31.5 percent in the control group.

“It gets the kids back to school and the parents back to work,” said Pariser.

The study, involving children in 11 states, did not compare the ivermectin to any other treatment.

However, in a previous study that did test other drugs as well, Pariser and his colleagues note that ivermectin showed a similar one-day success rate of 92.4 percent while malathion, an insecticide sometimes used to treat lice, cleared 82.4 percent of patients after one day.

“A topical drug formulation is indeed welcome and is expected to have less risk of systemic adverse events,” Dr. Oliver Chosidow of Henri-Mondor Hospital in Creteil, France, and Bruno Giraudeau of University Francois-Rabelais in Tours, France, said in an editorial published with the new study in the New England Journal of Medicine.

But they advised that more-established techniques, such as treatments with permethrin or pyrethrin, or even malathion in cases of resistance, should be tried before using ivermectin.

“Ivermectin should be the last choice, whether topical (for still-infested persons) or oral (especially for mass treatment),” they said.

Interviewed by Reuters Health by phone and e-mail, Chow speculated that more than one application of ivermectin lotion might be necessary because the treatment didn’t work in all cases.

“Knowing that new lice could re-hatch in seven to 10 days if ivermectin didn’t completely kill all nymphs, live lice and newly laid nits, I wonder if a second application will be recommended,” she said. “I would still advocate nit picking at this point.”

“If you do this, think about retreating and continue to be very vigilant,” she said.

SOURCE: http://bit.ly/Yor2zt New England Journal of Medicine, online October 31, 2012.

Medications/Drugs News Headlines – Yahoo! News

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Court rules against Polish rocker who tore up Bible

WARSAW (Reuters) – Poland‘s Supreme Court opened the way on Monday for a blasphemy verdict against a rock musician who tore up a Bible on stage, a case that has pitted deep Catholic traditions against a new desire for free expression.

Adam Darski, front man with a heavy metal group named Behemoth, ripped up a copy of the Christian holy book during a concert in 2007, called it deceitful and described the Roman Catholic church as “a criminal sect”.

His supporters say it was an act of artistic expression, but conservatives say he offended the sensibilities of Catholics in Poland, the homeland of the late Pope John Paul II and one of the religion’s most devout heartlands in Europe.

The Supreme Court was asked to rule on legal arguments thrown up by the musician’s trial in a lower court on charges of offending religious feelings.

It said a crime was committed even if the accused, who uses the stage name Nergal, did not act with the “direct intention” of offending those feelings, a court spokeswoman said.

That interpretation closed off an argument used by lawyers for Darski, who said he had not committed a crime because he did not intend to offend anyone.

The lower court will now decide if he is guilty. The maximum sentence is two years in jail, under Poland’s criminal code. However, it is extremely rare for anyone convicted of this kind of crime in Poland to serve prison time.

“(The decision) is negative and restricts the freedom of speech. The court decided that this is allowed in a democratic system,” Jacek Potulski, a lawyer for Darski, told Reuters.

He said he was not giving up. “We are still arguing that we were dealing with art, which allows more critical and radical statements,” the lawyer said.

Ryszard Nowak, a conservative former member of parliament who has for years been lobbying for the musician’s conviction, said he had been vindicated.

“The Supreme Court said clearly that there are limits for artists which cannot be crossed,” Nowak told Polish television.

The Catholic church and its teachings have been at the heart of Polish life for generations, but changes in society are challenging the dominance of the faith.

Opinion polls show that while 93 percent of Poles identify themselves as Catholics, the proportion who attend church or pray regularly is in decline, especially among young people.

Large parts of Polish society have also started to drift away from some of the church’s teachings, especially its ban on contraception and its opposition to homosexual partnerships.

“When it comes to bishops’ opinions on controversial social issues, I listen to them, but I don’t treat them as an absolute authority,” said Aleksandra Pulchny, a 22-year-old law student from Rybnik, in southern Poland.

In one indication of the changes in society, the blasphemy trial does not appear to have harmed Darski’s show business standing. He is one of four judges on “The Voice of Poland,” a talent show broadcast on national public television.

(Additional reporting by Rob Strybel; Editing by Michael Roddy)

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Northeast back to business after Sandy's hard hit

NEW YORK (Reuters) - Millions across the U.S. Northeast stricken by massive storm Sandy will attempt to resume their normal lives on Wednesday as companies, markets and airports reopen despite grim projections of power and mass transit outages around New York for several more days.

With six days to go before the November 6 elections, President Barack Obama will visit flood-ravaged areas of the New Jersey shore, where the storm of historic proportions made landfall on Monday. As his guide, he will have Republican Governor Chris Christie, a vocal backer of presidential challenger Mitt Romney who has nevertheless praised Obama and the federal response to the storm.

Leaders at all levels had immense amounts of work to do to bring a semblance of normality back to the densely populated Eastern Seaboard.

Sandy, which killed 40 people in the United States, pushed inland by dumping several feet of snow in the Appalachian Mountains, more than 8.2 million homes and businesses remained without electricity across several states as trees toppled by fierce winds tore down power lines.

Subway tracks and commuter tunnels under New York City, which carry several million people a day, were under several feet of water. The lower half of Manhattan remained without power after a transformer explosion at a Con Edison substation Monday night.

Hit with a record storm surge of nearly 14 feet of water, New York City likely will struggle without subways for days, authorities said. Buses were operating on a limited basis and many residents were walking long distances or scrambling to grab scarce taxi cabs on the streets.

Assessing the damage, officials with New York's Metropolitan Transportation Authority said they would release a timetable of their recovery plans sometime on Wednesday.

Despite much of the city's financial district being damaged by flooding, officials planned to reopen financial markets on Wednesday as well. How much activity could take place remained to be seen, however, as many workers may be unlikely to get to work without subways and commuter railroads from the suburbs.

Christie took a helicopter tour of the Jersey shore on Tuesday and saw boats adrift, boardwalks washed away, roads blocked by massive sand drifts and other destruction. He stopped in the badly damaged resort towns of Belmar and Avalon.

"I was just here walking this place this summer, and the fact that most of it is gone is just incredible," he said at one stop.

Christie said it could be seven to 10 days before power is restored statewide. He also said residents could not yet return to homes on the shore's battered barrier islands.

WAITING FOR RESCUE

Obama faces political danger if the government fails to respond well, as was the case with his predecessor George W. Bush's botched handling of Hurricane Katrina in 2005.

Thousands of residents of Hoboken, New Jersey, just across the Hudson River from Manhattan, were stranded in their homes due to flooding, the mayor said.

"We have, probably, about 20,000 people that still remain in their homes, and we're trying to put together an evacuation plan, get the equipment here," Hoboken Mayor Dawn Zimmer told MSNBC television.

The remains of Hurricane Sandy slowed to 8 mph over Pennsylvania, with maximum sustained winds of 40 mph and was expected to continue north toward western New York and Canada, the National Weather Service said.

The slowed pace meant it was dumping a lot of snow on the Appalachian Mountains, with nearly 30 inches recorded in Red House, Maryland.

Blizzard warnings and coastal flood warnings for the shores of the Great Lakes were in effect. The western extreme of Sandy's wind field generated gusts of up to 60 mph on the southern end of Lake Michigan and up to 35 mph in Chicago, the weather service said.

The storm killed 22 people in New York City, among 27 total in New York state, while six died in New Jersey. Seven other states reported fatalities. One disaster modeling company said Sandy may have caused up to $15 billion in insured losses.

Sandy hit the East Coast with a week to go to the November 6 presidential election, dampening an unprecedented drive to encourage early voting and raising questions whether some polling stations will be ready to open on Election Day.

Obama and Romney put campaigning on hold for a second day on Tuesday, but Romney planned to hit the trail in Florida on Wednesday and Obama seemed likely to resume campaigning on Thursday.

BROADWAY IS BACK

Sandy became the biggest storm to hit the United States in generations when it crashed ashore with hurricane-force winds on Monday near the New Jersey gambling resort of Atlantic City.

Two of the area's major airports - John F. Kennedy International in New York and Newark Liberty International - planned to reopen with limited service on Wednesday.

New York's LaGuardia Airport, the third of the airports that serve the nation's busiest airspace, was flooded and remained closed.

Nearly 19,000 flights have been canceled since Sunday, according to flight tracking service FlightAware.com.

On Broadway, the Theater League announced that most shows would resume performances on Wednesday. Shows had been canceled since Sunday due to the storm.

Sandy forced New York City to postpone its traditional Halloween parade, which had been set for Wednesday night in Greenwich Village.

(Additional reporting by Daniel Bases, Michael Erman, Anna Louie Sussman, Ed Krudy, Chris Michaud and Scott DiSavino in New York and Ian Simpson in West Virginia; Writing by Ellen Wulfhorst; Editing by Bill Trott)

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Hurricane’s death toll rises to 65 in Caribbean

PORT-AU-PRINCE, Haiti (AP) — As Americans braced Sunday for Hurricane Sandy, Haiti was still suffering.

Officials raised the storm-related death toll across the Caribbean to 65, with 51 of those coming in Haiti, which was pelted by three days of constant rains that ended only on Friday.

As the rains stopped and rivers began to recede, authorities were getting a fuller idea of how much damage Sandy brought on Haiti. Bridges collapsed. Banana crops were ruined. Homes were underwater. Officials said the death toll might still rise.

“This is a disaster of major proportions,” Prime Minister Laurent Lamothe told The Associated Press, adding with a touch of hyperbole, “The whole south is under water.”

The country’s ramshackle housing and denuded hillsides are especially vulnerable to flooding. The bulk of the deaths were in the southern part of the country and the area around Port-au-Prince, the capital, which holds most of the 370,000 Haitians who are still living in flimsy shelters as a result of the devastating 2010 earthquake.

Santos Alexis, mayor of the southern city of Leogane, said Sunday that the rivers were receding and that people were beginning to dry their belongings in the sun.

“Things are back to being a little quiet,” Alexis said by telephone. “We have seen the end.”

Sandy also killed 11 in Cuba, where officials said it destroyed or damaged tens of thousands of houses. Deaths were also reported in Jamaica, the Bahamas and Puerto Rico. Authorities in the Dominican Republic said the storm destroyed several bridges and isolated at least 130 communities while damaging an estimated 3,500 homes.

Jamaica’s emergency management office on Sunday was airlifting supplies to marooned communities in remote areas of four badly impacted parishes.

In the Bahamas, Wolf Seyfert, operations director at local airline Western Air, said the domestic terminal of Grand Bahamas‘ airport received “substantial damage” from Sandy’s battering storm surge and would need to be rebuilt.

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